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Your metabolism slows down to conserve energy, and hormonal changes may increase your appetite

Theoretically, phellodendron might also inhibit CYP2C9

Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease

These effects are seen even outside of diabetes control.[ref] Decreased colon cancer mortality: A 5-year mortality study in colon cancer patients showed that GLP-1 RA use decreased mortality risk by 60% in obese patients.[ref] Decreased risk of substance abuse: A large 2026 study using data from the VA showed that GLP-1 RA drugs reduce the risk of developing a substance addiction (drugs, alcohol)