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Importantly, these skin-related side effects were generally mild to moderate in severity and did not result in the discontinuation of retatrutide or placebo

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Our analysis indicates that there is no significant influence from unmeasured confounding variables (E-values for the point estimates [lower limits of the CI] were 2.90 [3.32), 1.54 [1.92), and 2.09 [2.39) for mortality, MACE, and MAKE, respectively)

16 While GLP-1s hold promise, the evidence is not yet strong enough to call them an Alzheimers treatment or proven prevention tool