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5A, B)are consistent with the central gain-based predictions when evaluated 8 wks post-treatment
Gut dysbiosis can lead to higher concentrations of these hormones, which can inhibit hormone signaling and alter energy metabolism ( N Engl J Med , 2024)
Key Phase 3 trials include: TRIUMPH-1: Retatrutide for obesity without type 2 diabetes TRIUMPH-2: Retatrutide for type 2 diabetes TRIUMPH-3: Retatrutide for obesity with type 2 diabetes TRIUMPH-4: Retatrutide for metabolic dysfunction-associated steatohepatitis (MASH) Results from these trials are expected between 2025 and 2027
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