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The recent discovery of the small molecule N6F11, which binds the tripartite region of Trim25 and promotes proteasome-degradation of GPX4 in pancreatic cancer cells, while sparing immune cells and the anti-tumoral response of the microenvironment, could represent a major clinical breakthrough for the use of GPX4 inhibitor/degrader [61]
For example, some studies have suggested that GLP-1 receptor agonists may assist in lowering high blood pressure, improving cholesterol levels, and reducing inflammation
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