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452.Clodi K, Asgary Z, Zhao S, Younes M, Wimmer D, Cabanillas F, Andreeff M, Younes A: B cells of Hodgkins disease (HD) may contribute to Reed-Sternberg (RS) cells survival by providing CD40 ligand (CD40L) survival signals in vivo
Although rare, alpha-lipoic acid may cause insulin autoimmunity (see Concerns and Cautions)
Additionally, obesity itself can contribute to gut dysbiosis, creating a vicious cycle
Pharmacokinetic-pharmacodynamic modeling could optimize dosing regimens based on target tissue exposure and response relationships
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