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Vitamin B12 is important for growth, cell reproduction, blood formation, and protein and nerve metabolism

Notably, a slowing or even reversal of disability stemming from potent medical immunosuppression or bone marrow transplantation should not be necessarily taken as evidence of a primary immune pathogenesis, because reducing a toxic inflammatory overlay could independently slow a picture of underlying progressive degeneration

The Patient-Reported Outcomes in PD (PRO-PD) is the primary outcome measure, ranging from 0 (asymptomatic) to 2500 (severe) to assess PD severity

This reduction contributes to fatigue, sluggish metabolism, and decreased cognitive performance