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The primary mechanisms of action include: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner, which helps lower blood glucose levels without causing hypoglycaemia when used alone [17] [18] Suppressing glucagon release from pancreatic alpha cells, reducing hepatic glucose production Slowing gastric emptying , which prolongs satiety and reduces postprandial glucose excursions Reducing appetite through central nervous system pathways, particularly in the hypothalamus, leading to decreased caloric intake and weight loss It's important to note that while GLP-1 receptor agonists have a low risk of hypoglycaemia when used alone, this risk increases when combined with insulin or sulfonylureas
Sanyal AJ (2024)
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