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Importantly, unlike -adrenergic stimulationinduced increases in myocardial cAMP, which enhance contractility, GLP-1 showed negative inotropic effects in rodent cardiac myocytes, implicating a compartmentalized mechanism of cAMP production away from the contractile apparatus (53)

The GLP-1 receptor antagonist, exendin-(9-39), has been used to demonstrate physiologic effects of endogenous GLP-1 in human studies

Orforglipron (Foundayo) is a more convenient option than GLP-1 injections, but is not as clinically effective as GLP-1 injections