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Although semaglutide and tirzepatide are both injectable medications designed to treat type 2 diabetes and support weight loss, they work in different ways
Wider metabolic improvements, such as better metabolic control and reduced chronic stress, may normalize LH pulses and support ovulation in individuals with metabolic-driven anovulation
Consequently, on top of the beneficial effect of weight loss caused by GLP-1 analogues these drugs also cause a substantial reduction of the glycemic load (GL = carbohydrate intake X Glycemic index), which per se reduces hyperinsulinemia and causes weight loss [22], reduce diabetes risk [23], inflammation [24], and cardiovascular risk [25]
Employers discontinuing coverage of GLP-1 medications should be aware that the health benefits their members attain will likely be lost over a little more than a year unless the members find a way to continue on these medications.
