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Effect of tirzepatide on blood pressure and lipids: a meta-analysis of randomized controlled trials

Materials and methods: To explore the potential genetic factors involved in the risk of T2D, we gathered the genotype information of two large T2D genetic datasets (~500,000 participants from the UK Biobank, ~70,000 individuals from the 70KforT2D)

However, in vitro studies have yet to find a direct effect of metformin on the activity of DPP4 [58], suggesting that any effect of metformin on DPP4 activity may be indirect, possibly by influencing hepatic production of DPP4 [56, 64]