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These peptides activate MRGPRX2, a mast-cell receptor that fires on positively charged, aromatic molecules and releases histamine into the tissue. Sodium and chloride ions screen the peptides positive charge, so the receptor sees less of it and the welt shrinks

doi:10.1136/bmjopen-2015-008222 Goto F, Nakai K, Kunihiro T, Ogawa K

higher doses are not universally better an appropriately dosed formula matched to your body size, health status, and goal consistently outperforms a maximal-dose approach, particularly for anyone with kidney disease, hypertension, or cardiovascular conditions

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