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Dox pretreatment alone delayed the onset of ferroptosis (i.e., increased D O ) in response to erastin2 in Control cells capable of expressing p21, albeit not to the same extent as nutlin-3 treatment (Fig 2B and C)
Despite these advances and their significant therapeutic potential, the molecular mechanisms underlying the potent cytoprotective effects of BPC157 remain largely undefined, limiting its full clinical translation
Similarly, liraglutide dosed at approximately 0.55 mg daily was shown to significantly improve 24-h glycaemia in subjects with type 2 diabetes after 8 days of treatment, based on glucose AUC values
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