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Patients who wish to use resveratrol for its cardiovascular polyphenol effects should start at 100 to 250 mg/day, establish a blood-pressure baseline before starting, monitor twice daily for the first two weeks, and notify their prescriber if systolic pressure drops below 110 mmHg or symptoms develop

However, another double-blind trial involving 108 Crohns disease patients did not find boswellia superior to placebo for maintaining remission (Holtmeier 2011)

The unfortunate truth is that big risk signals (lets say the kind you get from drinking antifreeze) can be spotted from the anecdotal experience of people in the world just trying things, but small-but-serious risk signals (lets say cardiovascular disease with tofacitinib) are really hard to identify without a proper trial or a proper observational study