does semaglutide affect sperm GLP-1s' Next Target: Male Infertility? Can Weight Loss Drugs Affect

For example, people with a history of heavy drinking who took semaglutide (the active ingredient in Ozempic and Wegovy) reported fewer alcohol cravings, drank less when they did drink and had fewer heavy drinking episodes than those who took a placebo, according to a 2025 double-blind, randomized clinical trial published in JAMA Psychiatry

Healthcare providers start patients on a low dose of semaglutide and gradually increase the dose, which gives the body time to adjust to the medicine

These obstacles exist despite broad recognition of GLP-1 efficacy

Clinical trials for GLP-1 agonists have reported musculoskeletal side effects such as back pain and muscle pain in a small percentage of participants, but joint pain specifically has not emerged as a consistent or significant adverse event across the class