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This preference shift supports the theory that GLP-1 class medications fundamentally alter food reward processing in the brain, not just hunger signaling

It competitively binds p53, displacing endogenous FOXO4 in senescent cells (Baar et al., 2017) 24-72 hours: Freed p53 translocates to mitochondria in senescent cells, triggering the intrinsic apoptotic cascade

While less common than injection-site irritation, other typical side effects for sermorelin may include ( 5 ): Itching Trouble swallowing Dizziness Flushing Nausea Headaches Overtiredness Changes in mood Trouble sitting still Headaches and nausea from sermorelin use may be linked to changes in hormone signaling or fluid balance, but they are usually temporary For most men, these side effects are mild, short-lived, and manageable with proper guidance from a provider

Most dermatologists and researchers agree that GLP-1 hair loss is primarily triggered by the rapid weight loss these drugs produce, not by the drug itself damaging your hair follicles