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Plasminogen activator inhibitor-1 (PAI-1) is the body primary brake on clot dissolution
The guiding principle is to find the lowest effective dose that comfortably sustains continued outcomes for the long term, rather than rushing everyone to the maximum dose in the minimum time
This is a critical issue, as a decrease in muscle mass leads to a reduction in basal metabolic rate [41, 42], which could hinder the long-term benefits of obesity treatment by impairing the overall metabolic profile
Dehydration and kidney function exist on a spectrum
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