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For the research context the article is key for understanding why the amylin + GLP-1 combination makes mechanistic sense

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More compelling evidence is lacking

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Figure 2 The clinically most relevant and important action of DPP-4 inhibitors is the endogenous elevation of the incretin hormone concentration of GLP-1 that consecutively leads to a glucose-dependent stimulation of insulin secretion and an inhibition of glucagon secretion (10)

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One of the most significant advancements in this field is the development of PT2385, a first-in-class, orally bioavailable, selective HIF-2 inhibitor

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