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Discontinuation rates due to gastrointestinal adverse effects ranged from 4% to 7% across clinical trials
people with alcohol use disorder, which decreases folate absorption and accelerates its breakdown
The degradation routes do not even belong to the same branch of chemistry: the peptides degrade by hydrolysis, isomerization and oxidation, while the copper complex changes by ligand exchange, by reduction of the metal, and by displacement of copper by any competing binder that reaches it
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