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Although the SPH domain alone cannot activate c-MET, mutations that disrupting the interaction between HGF-SPH and c-MET-SEMA significantly reduce HGF-induced c-MET activation, validating the functional importance of this interaction 15

Esta propriedade est diretamente relacionada sua origem gstrica: ele resiste degradao enzimtica no estmago, o que abre caminho para uma administrao oral uma vantagem considervel em comparao com outros peptdeos que necessitam obrigatoriamente de injeo