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Clin Ther 2010;32(4):710-713

They measure fundamentally different things

10.1097/01.aud.0000191942.36672.f3 28 HightN

exenatide and lixisenatide, are based on a protein derived from saliva of the Gila monster, and only share roughly 50% of the homology of GLP-1, which could trigger immunogenicity