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Women are nearly twice as likely to develop anxiety disorders, potentially due to enhanced HPA axis activation under stress and modulatory effects of sex hormones on GABAergic and glucocorticoid signaling (Jaggar et al., 2020)
Importantly, by immunohistochemical (IHC) staining of xenograft tumor tissues, we found that knocking down ACTL6A expression significantly decreased the level of Ki67, a proliferation marker, and increased that of 4-hydroxy-2-noneal (4-HNE) 45 , a lipid peroxidation marker (Fig
This can weaken the bodys antioxidant defenses, leading to more oxidative damage and a higher risk of multiple myeloma
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