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In senescent endothelial cells induced by OGD, treatment with FOXO4-DRI led to a significant increase in the expression of BAX and cleaved caspase-3 (c-Caspase-3), while the expression of BCL2 notably decreased

It is used as an adjunct to increased physical activity and a reduced-calorie diet for chronic weight management in adults with a body mass index (BMI) of at least 30 kg per m2 or a BMI of at least 27 kg per m2 with weight-related comorbidities such as type 2 diabetes mellitus, hyperlipidemia, or hypertension

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