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The catalase gene promoter and 5'-untranslated region variants lead to altered gene expression and enzyme activity in vitiligo
It can be beneficial for a wide range of conditions, including chronic infections, autoimmune diseases, arthritis, cardiovascular conditions, and more
Previously, we showed that TG2 mediates crystallin, caspase 3, and collagen crosslinking in response to oxidative stress, hypoxic stress, and DNA damage, which leads to cataract formation, apoptotic resistance, and fibrotic development, respectively 4,5,6
Such events can precipitate extensive cardiomyocyte death, resulting in pronounced cardiac function deterioration and, in severe cases, life-threatening complications ( Myocardial ischemia constitutes the predominant mechanism underlying CHD pathophysiology and serves as the central pathological process
