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For these regions, the side chains were stubbed in the final PDB models if no robust density was present in the EM maps
They'd move around, they were young
If future research shows that the cocktails effectively reverse cell aging in mice, clinical trials will be necessary to find whether they can be applied to humans
In contrast, the Grooved Pegboard Test, a commonly used measure of fine motor coordination and dexterity, demonstrates a broader dynamic range and has been shown to decline progressively with disease worsening, making it a more reliable response biomarker in longitudinal studies [512]
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