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The results of Look AHEAD do not row against the implementation of lifestyle changes in patients with type 2 diabetes
Briefly, an inverse correlation between IGF-1 (IGF-1/IGFBP-3 ratio) circulating levels and several markers for obesity, MetS, T2D, and CVD has been found
The neurocognitive and neuropsychiatric deficits change CNS immune and glial cells and the negative effect on neuronal pathophysiology is mainly due to myelin homeostasis and plasticity disturbance, hippocampal neurogenesis impairment with neurotoxic astrocyte reactivity (50)
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