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The peak-to-trough variation in drug levels with daily oral dosing versus weekly injectable dosing may also affect overall efficacy, particularly for outcomes like appetite suppression that benefit from steady drug levels
For individuals with sensitive stomachs, taking tablets with a small amount of water or immediately before a light meal may help prevent any digestive discomfort
The gut microbiota can also alter drug metabolism, affecting therapeutic efficacy and toxicity
WADA has banned it under the S0 Unapproved Substances category
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