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This is the application area with the deepest preclinical history, and it is also where oral administration has a particularly direct anatomical rationale - the compound passes through the GI tract it was originally studied in relation to

Human data lacking To date, most (if not all) data is preclinical (rodents, cell culture)

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Researched applications The published preclinical literature documents the effects of BPC-157 in the following areas (mostly in animal models): Tendon and ligament healing , Achilles tendon, medial collateral ligament (MCL, the ligament on the inner side of the knee), tendinopathy models Muscle injuries , quadriceps (front thigh), gastrocnemius (calf muscle), transections and contusions Bone and joint healing , osteoarthritis models, fracture healing, periodontal tissues (around the teeth) Gastrointestinal diseases , gastric lesions caused by alcohol or NSAIDs (ibuprofen, diclofenac), colitis, IBD models (Crohns disease), fistulas Hepatoprotection , protection of the liver against toxic damage (paracetamol overdose, CCl, alcohol) Vascular healing , endothelial dysfunction, thromboses, healing of vascular anastomoses after surgery, thrombocytopenia (low platelet count) Skin wounds , acute as well as diabetic wounds, burns Nerve regeneration , peripheral (sciatic nerve crush) as well as central (cerebral ischemia models, i.e