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Moreover, the ER-localized protein VAPB interacts with the outer mitochondrial membrane (OMM) protein PTPIP51 to form a transmembrane complex, stabilizing MAMs architecture and facilitating targeted Ca 2+ transfer from the ER to mitochondria [70]
However, clinical efficacy is often limited by a pattern of short-term response followed by long-term resistance [74]
doi: 10.1136/ard-2024-225645 106 WangTZhaoXLiJYinCJiangBXieJet al
It gradually reduces melanin production rather than causing overnight results
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