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Sotorasib binds covalently to the switch II pocket formed by the KRAS G12C mutation, inhibiting KRAS activity and overcoming resistance
Most clinical studies lasted 12 weeks
They had threshold concentrations that they would deem inappropriately high, perhaps for safety, perhaps because they thought it was an unfair advantage
2.3.1.4 Outcome measures The comprehensive evaluation included baseline characteristics encompassing BMI (kg/m 2 ), duration and type of infertility, antral follicle count (AFC), and basal serum levels of follicle-stimulating hormone (FSH), LH, E2, and progesterone (P)
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