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Tesamorelin gained FDA approval in 2010 specifically for reducing visceral adipose tissue in HIV-associated lipodystrophy, with clinical trials showing 1518% reductions in visceral fat after 26 weeks at 2mg daily dosing
Full-length thymosin beta-4 contains 43 amino acids and has a molecular mass close to 4.9 kDa
Cerebral edema compresses healthy tissue
Safety and efficacy inferences are extrapolated from native rhIGF-1 clinical data, which involved disease populations, not healthy adults
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