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Analysis of specific topic This literature review was conducted following the PICO Framework, with details available in Supplementary material 1

According to the cryo-EM analysis, it engages the ECD, extracellular loop 2, and transmembrane helices 1, 2, 3, and 7 while notably not contacting helices 4, 5, and 6, which the peptide relies on

The Effects and Mechanisms of Mitochondrial Nutrient -Lipoic Acid on Improving Age-Associated Mitochondrial and Cognitive Dysfunction: An Overview