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Key data point: in SURMOUNT-1, tirzepatides dual GIP/GLP-1 action produced about 21 percent mean weight loss at 72 weeks
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3 Beyond weight loss, the highest dose delivered meaningful reductions in cardiovascular risk factors: triglycerides fell by an average of 37.0%, non-HDL cholesterol by 16.5%, systolic blood pressure by 9.3 mmHg, waist circumference by 7.5 inches and high-sensitivity C-reactive protein by 51.2%
Bulk RNA-Seq data suggested reduced levels of Cyp2e1 in mice treated with GLP-1RA when given free access to a regular diet or a liquid ethanol diet (Supplementary Fig
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