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Acosta, MD, PhD, assistant professor of medicine at Mayo Clinic in Rochester, Minnesota, and colleagues wrote in a study published in Diabetes , Obesity and Metabolism
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Thus, we have demonstrated that GSH-targeted therapy selectively kills PC cells in an oxidative stress-dependent manner and that the differences in basal ROS level and antioxidant scavenging capacity induced by stratified expression of VRK2 can well account for the heterogeneous sensitivity to GSH inhibition
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