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Iron overload-induced ROS generation, similar to p53 acetylation, also promotes M1 polarization (98, 99)

The medication works by mimicking the incretin hormone GLP-1, which enhances insulin secretion, suppresses glucagon release, slows gastric emptying (though this effect may attenuate over time), and reduces appetite through central nervous system pathways

Disease-Modifying Antirheumatic Drugs (DMARDs): Such as methotrexate or sulfasalazine, to slow disease progression and protect joints