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The compound attracts research attention because its effects span multiple biological systems simultaneously GI tract, musculoskeletal, neurological, cardiovascular which is unusual for a 15-amino-acid peptide and suggests it interfaces with conserved repair signalling pathways rather than tissue-specific receptors

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Research has found that doxycycline can inhibit p38/MAPK activation and total MMP activity in RPE cells, thereby reducing their proliferation, migration, adhesion, and contraction (114)