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Three of our favorite at-home testing companies Everlywell, LetsGetChecked, and myLAB Box offer kits that measure various aspects of AFAB womens health, including a wide range of female hormones

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The constipation pathway: Predominant GLP-1 receptor expression in the colon Slowed peristalsis exceeds the gut's ability to adapt Increased water absorption Hard, infrequent stools The diarrhea pathway: Predominant GLP-1 receptor expression in the small intestine Slowed small bowel transit allows bacterial overgrowth or malabsorption Osmotic load in the colon from unabsorbed nutrients Loose, frequent stools The mixed pathway (most common): Early diarrhea (weeks 1-4) from acute gastric retention and bile acid malabsorption Transition to constipation (weeks 4-12) as colonic adaptation lags behind gastric adaptation Resolution to normal or near-normal bowel habits after 12-16 weeks A 2024 paper in Gut (Acosta et al.) measured GLP-1 receptor density in colonic biopsies from 86 patients starting semaglutide

Mitochondrial and synaptic abnormalities in ASD-related syndromes The growing body of evidence reveals that the ability of mitochondria to adapt to the changing environment and energy demand is impaired in various ASD-related syndromes [325, 326]