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This occurs when there's an imbalance between the generation and buildup of reactive oxygen species (ROS) within cells and tissues and the ability of innate biological systems and dietary antioxidants to eliminate these reactive byproducts

In Phase 3 TRIUMPH-1 (May 21, 2026), the 12 mg arm averaged 28.3% weight loss at 80 weeks, and a higher-BMI subgroup reached 30.3% at 104 weeks

Like all medication, semaglutide comes with side-effects and risks - including nausea, stomach pain, vomiting and diarrhoea

However, the mechanism of action of GIP in this paradox and the extent of its role in these outcomes remains unclear