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Blood glucose regulation improves because semaglutide enhances insulin secretion in response to elevated blood sugar
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For determining metabolic parameters [O2, CO2, food consumption, respiratory exchange ratio (RER), energy expenditure] and activity tracking, the mice were acclimated to housing in an Oxymax/CLAMS-HC metabolic chamber system (Columbus Instruments) for 24 h and data from a continuous 24 h period was then recorded and analyzed
Acetaldehyde is metabolized by acetaldehyde dehydrogenase (ALDH genes) into acetic acid, which is non-toxic
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