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Risk factors include: genetics previous injuries being over the age of 50 menopause having an occupation that requires kneeling, climbing, or heavy lifting obesity Mandelbaum and Baker agreed that weight is the number one factor in the development and progression of osteoarthritis
Phase 2 trials published in the New England Journal of Medicine showed participants losing an average of 24.2% of their body weight at the 12mg weekly dose over 48 weeks
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