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Moreover, IPP can be used to synthesize ubiquinone, which can be reduced to ubiquinol (reduced CoQ) by FSP1, subsequently trapping lipophilic radicals that mediate lipid peroxidation and ultimately impeding ferroptosis [16, 149]
ACSL4 catalyzes the reaction of PUFAs to polyunsaturated fatty acid-coenzyme A (PUFA-CoA), and then the PUFA-CoA undergoes esterification by lysophosphatidylcholine acyltransferase 3 (LPCAT3) to become polyunsaturated fatty acid-phospholipids (PUFA-PLs), which are then oxidized by reactive oxygen species (ROS) to cytotoxic phospholipid hydroperoxides (PL-OOH), leading to cell death through membrane modification (Liu et al., 2025
8X Blend L-Carnitine (20mg) / L-Arginine (20mg) / Methonine (25mg) / Inositol (50mg) / Choline (50mg) / B6 (25mg) / B5 (5mg) / B12 (1mg) Description A multi-component research material supplied for controlled research environments
SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2
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