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Bernacki J, Dobrowolska A, Nierwiska K, Maecki A
Its stability depends on the metal staying coordinated to the tripeptide, which makes it sensitive to pH, since the deprotonated amide nitrogen that helps hold the copper is pH-dependent, and outright incompatible with two whole classes of common additive
This cyanocobalamin complex is then excreted in the urine, thereby detoxifying the cyanide and restoring cellular respiratory function
The weight-adjusted approach matters more for peptides with narrow therapeutic windows or those where body composition significantly affects distribution
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