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[56] Serum haptocorrin binds 80-90% of circulating B 12 , rendering it unavailable for cellular delivery by transcobalamin II
In addition, gene therapy based on transfection of mtDNA-complexed TFAM or recombinant TFAM to PD cybrid cells shows potential to restore mitochondrial bioenergetics of severely impaired nigral neurons, as TFAM is important for mtDNA maintenance (Keeney et al., 2009
Sun HL, Sun BL, Chen DW, Chen Y, Li WW, Xu MY, et al
However, most of the studies are done on animal models
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