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Differential diagnosis between MNTI and melanoma is raised in such cases by the presence of pigmented tumor cells, but melanoma is extremely rare in childhood and even more on oral mucosa

In in vitro conditions, erastin increased iron overload, oxidative stress and lipid peroxide production in human epidermal melanocytes [77]

The GSTZ1 gene that encodes glutathione S -transferase-zeta was mapped to chromosome 14q24.3