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Furthermore, an enhanced thromboxane (TXB) platelet biosynthesis was demonstrated in diabetic patients (Dav et al., 1990), together with increased platelet susceptibility to aggregating agonists [adenosine diphosphate (ADP), thrombin] and diminished sensitivity to anti-thrombotic molecules such as prostacyclin (PGI2) and nitric oxide (NO) (Vinik et al., 2001)

bile acid sequestrants or dietary adjustments may be necessary