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SDNN is the standard deviation of the time between beats and represents the total variation in heart rate, while RMSSD stands for root mean square of successive differences and represents variation between successive beats

[3] Prolonged therapy can unmask or exacerbate benign prostatic hyperplasia, raise prostate-specific antigen, worsen untreated obstructive sleep apnoea and is associated in some observational studies with a small but controversial increase in cardiovascular events, underlining the necessity for baseline and periodic monitoring of PSA, lipids and cardiovascular risk factors