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GLP-1 receptor agonists (semaglutide, liraglutide) are the only peptide-based medicines licensed by the MHRA for weight management in the UK and require a prescription
Commonly reported side effects include: Nausea and vomiting Diarrhoea or constipation Decreased appetite (which may be pronounced) Abdominal discomfort or bloating Injection site reactions (redness, bruising, or mild pain) Increased heart rate (a recognised class effect) In clinical trials, the majority of gastrointestinal side effects were described as mild to moderate in severity and tended to resolve over time as the body adjusted to the medication
These agents exhibit anti-inflammatory, cardioprotective, and neuroprotective effects, suggesting a broader therapeutic potential
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