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GLP-1s are contraindicated in individuals with a history of medullary thyroid carcinoma, a family history of such, or in patients with multiple endocrine neoplasia syndrome Type 2
If your resting pulse sits above 90 bpm for more than a week, hold the current dose before escalating
According to the Zepbound prescribing information, tirzepatide commonly causes nausea (24-29%), diarrhea (18-24%), vomiting (8-11%), constipation (16-17%), and abdominal pain (10-15%), with rates increasing at higher doses
Notably, GLP-1 significantly suppressed plasma pancreatic polypeptide concentrations following the first meal, 68 but this effect diminished substantially after the second test meal, 72 suggesting autonomic nervous system adaptation to continuous GLP-1 administration
