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Oxidative stress is involved in heat-induced cell death in Saccharomyces cerevisiae
GST mediated detoxification is critical for adaptation against xenobiotics including plant allelochemicals and synthesized pesticides
Studies have shown that when amyloid-beta and tau are increased, the cells ability to neutralize oxidative stress and mitochondria specific ROS is decreased leading to further tau hyperphosphorylation and neurodegeneration ( These redox imbalances also impact astrocytes, which normally synthesize GSH through the consecutive sections of two ATP consuming cytosolic enzymes
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