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40 In the FIGHT trial, long-term administration of liraglutide to HF and HFrEF patients with or without diabetes did not significantly improve LVEF after 24 weeks of treatment
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Although GLP-1 levels were not actually measured in that study (26), subsequent studies in glucose-intolerant rodent models did show that the improved glycaemic control following in vivo DPP-4 inhibition was associated with enhanced intact GLP-1 responses to glucose challenges (2729)
