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Collectively, these studies, ranging from molecular mechanisms to translational applications, systematically establish ferroptosis as a central link connecting metabolic disorders, oxidative stress, and structural damage to renal tubule, thereby providing a new theoretical basis and intervention targets for DKD diagnosis and therapy

For each animal, the brain tissue was dissected, snapped frozen with dry ice, and stored at 80C until biochemical analysis

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CagriSema showed better glycemic management and weight loss than either of its components as single agents